THE COMPARATIVE PHARMACOLOGY OF THE CYCLOHEXYLALKYLAMINES

¹ Department of Pharmacology, West Virginia University School of Medicine, Morgantown

2-Phenylethylamine, 2-phenyl-1-propylamine, 1-phenyl-2-propylamine and their N-methyl homologs have been compared with their cyclohexyl analogs. The unsubstituted phenylethylamine is more active as a pressor agent than phenylethyl methylamine, and these are both more active than the corresponding cyclohexylethylamines. Similarly, the phenylpropylamines, though less active than the phenylethylamines, are more active than their cyclohexyl analogs. On isolated smooth muscle, the reverse is true, with the hydrogenated compounds being more relaxant than the aromatic compounds, and the N-methyl homologs being more active than the unsubstituted compounds.