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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 3, 314-328, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL STUDIES ON ANALGESIC PIPERIDINE DERIVATIVES

Lowell O. Randall 1 and G. Lehmann 1

1 Pharmacology Lab., Hoffmann-La Roche, Inc., Nutley, New Jersey

A series of 50 derivatives of piperidine have been studied for analgesic action and other pharmacological properties.

Maximal analgesic potency is attained by introducing an alkyl group into the 3-position of these 1-, 4-, 4-substituted piperidines. Steric configuration determines the degree of analgesic potency. Four of these preparations are from four to eight times as potent as morphine. Qualitatively these compounds resemble morphine in pharmacological action.

Submitted on March 15, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.