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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 3, 277-281, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics


TISSUE DISTRIBUTION OF A TOXICANT FOLLOWING ORAL INGESTION OF THE GAMMA ISOMER OF BENZENE HEXACHLORIDE BY RATS

Edwin P. Laug 1

1 American Society for Pharmacology and Experimental Therapeutics, Atlantic City, New Jersey

1. Using the house fly as a sensitive test insect, a bio-assay method has been developed for the gamma isomer of benzene hexachloride.

2. Examination of the tissues of rats which had consumed gamma isomer in their diet has shown the presence of a substance having toxicologically identical characteristics to that of the gamma isomer.

3. Largest quantities of toxicant were found in fat and kidney tissues with measurable amounts in blood, liver, spleen, muscle, brain and adrenal.

4. Some excretion of toxicant occurs via the urine but little or none via the feces.

Submitted on March 6, 1948




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.