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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 2, 223-229, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

NIAARA; A DIGITALIS-LIKE COLOMBIAN ARROW POISON

K. Mezey 1, C. Uribe-Piedrahita 2, J. Pataki 2, and J. Huertas-Lozano 2

1 Javeriana University Medical School, Bogotá
2 The César Uribe-Piedrahita Research Laboratories, Bogotá, Colombia, S. A.

1. Niaara, an arrow poison from Colombia, S. A. is the latex of the tree Ogcodeia ternstroemiiflora Midbr.

2. An amorphous principle ("niaarin") having chemical and pharmacological properties characteristic of the cardiac glycosides has been isolated from the latex of this tree. Neither the crude nor pure materials have any curariform activity.

3. The intravenous LD50 in cats is 0.21 mgm./kgm. It is poorly absorbed from the gastro-intestinal tract.

4. Seven cases of congestive heart failure in man were successfully treated with niaarin.

Submitted on March 2, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.