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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 2, 175-179, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF DIPHENHYDRAMINE HYDROCHLORIDE AND EPINEPHRINE ON GLUCOSE METABOLISM IN THE RABBIT

Graham Chen 1 and Isabel G. Clarke 1

1 Research Laboratories, Parke, Davis and Company, Detroit, Michigan

The logistic function was found to fit the dose-response curve of epinephrine-hyperglycemia

The combined effect of diphenhydramine and epinephrine on blood glucose was investigated; their joint action on hyperglycemia was shown to be additive but different in nature. The hyperglycemic effect of diphenhydramine. HCl was apparently due to its central nervous stimulation since it could be inhibited by a depressant.

Submitted on February 17, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.