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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 2, 168-174, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE EFFECTIVENESS OF FIVE ANTIHISTAMINICS VS. HISTAMINE-INDUCED SPASM IN CANINE THIRY-VELLA LOOPS

Bradford N. Craver 1, Anne Cameron 1, and Fredrick F. Yonkman 1

1 Research Department, Division of Pharmacology, Ciba Pharmaceutical Products, Inc., Summit, New Jersey

The five antihistaminics: Antergan, Antistine, Benadryl, Neoantergan and Pyribenzamine were effective in non-toxic doses in preventing a histamine-induced spasm of the ileum in dogs with Thiry-Vella Loops. Since the drugs proved additive in their actions, it is presumed that they act by the same or very similar mechanisms.

Submitted on February 13, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.