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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 2, 142-146, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

A METHOD FOR THE QUANTITATIVE ESTIMATION OF THEOPHYLLINE IN BLOOD AND URINE: APPLICATION TO THE DOG

Albert J. Plummer 1

1 Department of Pharmacology, Boston University School of Medicine

A method for the quantitative determination of theophylline in blood and urine has been described.

The method is sensitive to 0.13 mgm. anhydrous theophylline per 100 cc. of blood or urine.

Caffeine, theobromine, uric acid, ethylene diamine and sodium acetate do not interfere with the determination nor does any normal blood property or constituent.

After 8 mgm. per kgm. theophylline (in aminophylline) intravenously administered to dogs the theophylline was no longer detected in the blood at the end of 90 minutes in 4 out of 5 dogs.

1.8% of the injected theophylline appears in the urine during this 90 minute period.

Submitted on January 31, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.