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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 2, 129-134, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE DETERMINATION OF 3-(ORTHOTOLOXYL)-1,2-PROPANEDIOL (MYANESIN) IN BODY FLUIDS AND TISSUES, AND ITS DISAPPEARANCE FROM THE BLOOD FOLLOWING INTRAVENOUS INJECTIONS IN THE DOG

Elwood Titus 1, Stanley Ulick 1, and Arthur P. Richardson 2

1 Division of Pharmacology, Squibb Institute for Medical Research, New Brunswick, New Jersey
2 School of Medicine, Emory University, Georgia

Analytical methods for 3-(orthotoloxyl)-1,2-propanediol (Myanesin) involving coupling with diazotized 2,4-dinitroaniline and colorimetric determinations of the formaldehyde resulting from periodate oxidation have been developed. Of these, the former is more generally applicable to plasma and urine. The latter, which may be used for plasma determinations, gives results in agreement with the coupling procedure.

The rate of disappearance of Myanesin from the blood of dogs receiving doses of 50 and 100 mgm. per kilogram has been measured.

Submitted on September 8, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.