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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 1, 109-113, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE CURARIFORM ACTIVITY OF d-N-METHYL-CHONDRODEN DRINE AND d-O-METHYL-N-METHYL-CHONDRODENDRINE

David F. Marsh 1, Clark K. Sleeth 1, and Eldon B. Tucker 1

1 Departments of Pharmacology and Medicine, West Virginia University School of Medicine, Morgantown

d-N-Methyl-chondrodendrine iodide and d-O-methyl-N-methyl-chondroden-drine iodide were compared with d-tubocurarine chloride pentahydrate and d-O-methyltubocurarine iodide trihydrate in rats, rabbits, cats, and man. d-N-Methyl-chondrodendrine (as the ion) is about one-half as paralysant as the isomeric d-tubocurarine in rats and rabbits, although only one-fourth to one-eighth as active in cats and man. d-O-Methyl-N-methyl-chondrodendrine is about equipotent with d-tubocurarine, but it is only one-sixth to one-eighth as active as its diastereosiomer, d-O-methyltubocurarine. All of these compounds have relatively little effect in intact animals other than lissive action on skeletal muscles.

Submitted on January 19, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.