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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 1, 1-9, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE INTRAVENOUS, SUBCUTANEOUS AND CUTANEOUS TOXICITY OF bis(beta-CHLOROETHYL) SULFIDE (MUSTARD GAS) AND OF VARIOUS DERIVATIVES

William P. Anslow Jr. 1, David A. Karnofsky 1, B. Val Jager 1, and Homer W. Smith 1

1 Department of Physiology, New York University College of Medicine, New York

The parenteral toxicity of bis(beta-chloroethyl) sulfide (mustard gas) and certain mustard derivatives has been studied in various species. Most derivatives of mustard are relatively non-toxic. Those which are toxic are shown to act in a different manner from mustard. These data support the hypothesis that mustard acts either per se or in the form of its first aqueous reaction product, beta-chloro-ethyl-ethylene sulfonium chloride.

We are indebted to Elesa Addis (Karnofsky), Mildred Bevelander, Betty Lou Ellis, Vera Hoie, Vera James, Penelope Smith and Lee Summers in the conduct of the experiments.

Submitted on July 11, 1947




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.