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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 4, 454-458, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE CURARIFORM ACTIVITY OF d-N-METHYL-ISOCHON-DRODENDRINE AND d-O-METHYL-N-METHYL-ISOCHONDRODENDRINE

DAVID F. MARSH 1 and M. H. PELLETIER 1

1 Department of Pharmacology, West Virginia University School of Medicine, Morgantown

d-N-Methyl-isochondrodendrine iodide and d-O-methyl-N-methyl-isochondrodendrine iodide were compared with d-tubocurarine chloride pentahydrate and d-O-methyltubocurarine iodide trihydrate in rats, rabbits, and cats. d-N-Methyl-isochondrodendrine (as the ion) is about 1/20 and d-O-methyl-N-methyl-isochondrodendrine 1/4 as paralysant as d-tubocurarine, which in turn is only 1/10 as active as d-O-methyltubocurarine. Like the tubocurarine compounds, these isochondrodendrine derivatives have relatively little effect in intact animals other than lissive action on skeletal muscles.

Submitted on January 2, 1948






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