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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 4, 443-446, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

ISODYNAMIC EQUIVALENTS OF DIGITOXIN CONGENERS AS TESTED ON HYPODYNAMIC MYOCARDIUM

WALLACE F. WHITE 1, JULIUS BELFORD 1, and WILLIAM T. SALTER 1

1 Laboratories of Pharmacology and Toxicology, Yale University School of Medicine, New Haven, Conn.

The inotropic effects of twelve pure "cardiac glycosides" upon isolated hypodynamic myocardium have been compared. The over-all comparison agrees closely with results reported for mean lethal dose in intact cats, although two compounds were displaced in order of sequence.

Submitted on December 10, 1947






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