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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 4, 411-413, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

HISTAMINE SHOCK IN MICE SENSITIZED WITH HEMOPHILUS PERTUSSIS VACCINE

I. A. PARFENTJEV 1 and MARY A. GOODLINE 1

1 Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Mayer and Brousseau (6) and Perry and Darsie, Jr. (7) recently reported some very comprehensive studies on anaphylaxis in mice, but the significance of [See table in the PDF file] histamine was not determined. However, in our own experiments it was found that H. pertussis vaccine injected into mice produced a hypersensitivity to histamine, which could be counteracted by the antihistamine agent Bromothen.It has not yet been determined whether the injection of H. pertussis vaccine into man can produce similar effects.

Submitted on October 29, 1947




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.