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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 4, 369-380, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF COMPOUNDS STRUCTURALLY RELATED TO HYDROXYTYRAMINE

A. M. LANDS 1, V. L. NASH 1, B. L. DERTINGER 1, H. R. GRANGER 1, and H. M. McCARTHY 1

1 Pharmacological Research Laboratory, Frederick Stearns and Co., Division of Sterling Drug Inc.

1. Racemic nor-epinephrine is distinctly more pressor than racemic epinephrine.

2. Inhibitory (sympathin I-mimetic) actions of nor-epinephrine are increased by N-alkyl substitution.

3. The structure of the N-alkyl group is an important factor influencing inhibitory potency.

4. Inhibitory effects are not prominent with those hydroxytyramine derivatives that do not contain the alcoholic hydroxyl of nor-epinephrine.

5. The significance of these findings is discussed.

Submitted on August 25, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.