EFFECT OF ACIDOSIS AND ANOXIA ON THE CONCENTRATION OF QUINACRINE AND CHLOROQUINE IN BLOOD

¹ Research Service, Third (New York University) Medical Division, The Goldwater Memorial Hospital, New York; Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, Baltimore

1. The concentration of quinacrine and of chloroquine in blood plasma and in erythrocytes was doubled during the administration of 10 per cent CO₂ in O₂ over a 2-hour period. The procedure induced an acidosis corresponding to a drop in blood pH from 7.4 to 6.9.

2. The concentration of drug in muscle tissue and in leucocytes remained unchanged within the errors of measurement. Elevation of plasma drug level in the presence of relatively unchanged tissue concentration indicates that acidosis alters the partition of drug between tissues and plasma.

3. Anoxia of moderate degree did not of itself change the concentration of drug in plasma or erythrocytes. Any small changes encountered were consistent with. associated acidosis. In severe asphyxia the combination of extreme anoxia and marked acidosis did give rise to exceptionally high elevation of drug level in plasma and in erythrocytes.

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