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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 3, 330-335, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

STUDIES WITH TETRAZOLE DERIVATIVES

V. Some Pharmacologic Properties Of Aminophenyl Tetrazoles

E. G. GROSS 1 and R. M. FEATHERSTONE 1

1 Department of Pharmacology, College of Medicine, State University of Iowa

The action of a group of aminophenyltetrazole derivatives on the central nervous system has been studied. The presence of a m-aminophenyl, but not the p-aminophenyl group, in either the 1 or 5 position of the tetrazole nucleus produced compounds having primarily depressant actions, depending upon the size of the aliphatic side chain. A schematic diagram of the relation of structure to pharmacologic activity in the 130 compounds of the complete series (1-4 and Group 5) is presented and discussed.

Submitted on November 19, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.