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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 3, 269-276, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

OBSERVATIONS ON THE COMPARATIVE PHARMACOLOGIC ACTIONS OF 6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEPTANONE (AMIDONE) AND MORPHINE

J. K. FINNEGAN 1, H. B. HAAG 1, P. S. LARSON 1, and M. L. DREYFUSS 1

1 Department of Pharmacology, Medical College of Virginia, Richmond; Pathological Laboratory, Chesapeake and Ohio Hospital, Clifton Forge, Virginia

By acute oral, subcutaneous and intravenous administration to rats, amidone is several times more toxic than morphine. On a subacute basis, amidone is but slightly more toxic than morphine to rats and dogs.

There is little evidence of development of tolerance to the depressant action of amidone in dogs.

Amidone produces a hyperglycemic response in dogs to which tolerance develops on continued administration.

Submitted on October 14, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.