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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 3, 249-259, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL PROPERTIES OF A NEW ANTIHISTAMINIC, 2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINDENE (THEPHORIN) AND DERIVATIVES

G. LEHMANN 1

1 Scientific Department, Hoffmann-La Roche, Inc., Nutley, New Jersey

Thephorin, 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene, one of three closely related pyridindene derivatives studied, proved to be a potent antihistaminic on isolated guinea pig's ileum, in the spray test, against intracardial histamine and against anaphylactic shock. In addition, Thephorin antagonizes spasmogenic effects of acetyl-choline, of Ba-ions and of epinephrine.

Submitted on October 14, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.