DIURETIC ACTION OF FORMOGUANAMINE IN NORMAL PERSONS

¹ Lederle Laboratories, Pearl River, N. Y.

1. Diuretic doses of 15 mg./kg. of formoguanamine were fed to a group of six dogs 72 times each, and 24 doses of 20 mg./kg. to a group of six rabbits without producing toxic effects.

2. In agreement with previous assays in rats and dogs, formoguanamine produces a significant diuresis and chloruresis in normal fasting persons in doses between 4 and 9 mg./kg.

3. Under standard conditions of test in human beings–administration of 350 ml. of 0.85% NaCl solution together with the diuretic–8 to 9 mg./kg. of formoguanamine removed 90 to 100 per cent of the introduced fluid in four hours.

4. Doses above 9 mg./kg. may produce thirst, prolonged diuresis and feeling of discomfort in the lumbar region.

5. Formoguanamine proved to be more consistent in diuretic activity than the xanthine diuretics under comparable conditions.