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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 2, 127-130, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

CURARIFORM ACTIVITY OF QUATERNARY AMMONIUM IODIDES DERIVED FROM CINCHONA ALKALOIDS

DAVID F. MARSH 1 and M. H. PELLETIER 1

1 Department of Pharmacology, West Virginia University School of Medicine, Morgantown

The curariform activity of quinidine methiodide, quinidine ethiodide, cinchonine methiodide, cinchonine ethiodide, cinchonidine methiodide, and cinchonidine ethiodide in comparison with quinine methiodide and quinine ethiodide was determined in rats, rabbits, and cats. The quinidine and cinchonidine compounds are most active and most toxic, the quinine compounds produce better lissive action with less fasciculation, and the cinchonine compounds are least active.

Submitted on July 28, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.