JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ERCOLI, N.
Right arrow Articles by WILSON, W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ERCOLI, N.
Right arrow Articles by WILSON, W.
Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 2, 121-126, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

INFLUENCE OF BAL ON THE TOXICITY AND CHEMOTHERAPEUTIC ACTIVITY OF MAPHARSEN

N. ERCOLI 1 and WILLIAM WILSON 1

1 Division of Pharmacology and Chemotherapy, Warner Institute for Therapeutic Research, New York City

The therapeutic activity of Mapharsen, under the influence of BAL, has been studied in relation to its toxicity in mice infected with T. equiperdum. It was found that: 1) The curative activity of the arsenical is inhibited by much lower doses of BAL than the trypanocidal activity. 2) The therapeutic activity of the arsenical is inhibited by relatively lower doses of BAL than the toxicity, as measured by the mortality figures. 3) In general, the higher the dose of the arsenical the more BAL proportionately is required for inhibition. 4) The extremely fast decrease in the curative action of Mapharsen, when given in conjunction with BAL, precludes the possibility of this form of combined chemotherapy.

Submitted on July 14, 1947




This article has been cited by other articles:


Home page
 Mol. Pharmacol.Home page
J.-R. Gurr, D.-T. Bau, F. Liu, S. Lynn, and K.-Y. Jan
Dithiothreitol Enhances Arsenic Trioxide-Induced Apoptosis in NB4 Cells
Mol. Pharmacol., July 1, 1999; 56(1): 102 - 109.
[Abstract] [Full Text]

Home page
 BloodHome page
A. Konig, L. Wrazel, R. P. Warrell Jr, R. Rivi, P. P. Pandolfi, A. Jakubowski, and J. L. Gabrilove
Comparative Activity of Melarsoprol and Arsenic Trioxide in Chronic B-Cell Leukemia Lines
Blood, July 15, 1997; 90(2): 562 - 570.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.