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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 1, 83-89, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF SINGLE DOSES OF 6-DIMETHYLAMINO-4-4-DIPHENYL-3-HEPTANONE (AMIDONE, METHADON, OR ‘10820’) ON HUMAN SUBJECTS

Harris Isbell 1, Anna J. Eisenman 1, Abraham Wikler 1, and Karl Frank 1

1 U.S. Public Health Service Hospital, Lexington, Kentucky

1. 5.0 mgm. subcutaneous doses of amidone elevated the pain threshold of non-addicts and former morphine addicts as much as 10-15 mgm. of morphine sulfate.

2. Respiratory rate, pulse rate, rectal temperature and systolic blood pressures were lowered by amidone.

3. 10-30 mgm. doses of amidone subcutaneously had no significant effect on the electrocardiogram.

4. 60-75 mgm. of amidone in divided doses had no significant effect on the blood sugar of former addicts.

5. 30-75 mgm. of amidone always produced sedation in former morphine addicts. The electroencephalographic pattern was sometimes shifted to the slow side after 30-mgm. doses.

6. 30 mgm., or more, of amidone subcutaneously regularly produced euphoria in former morphine addicts; 10-30 mgm. doses intravenously induced intense euphoria. Narcotic drug addicts would abuse amidone if it were freely available.

Submitted on September 19, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.