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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 1, 63-72, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF ATROPINE AND SCOPOLAMINE ON THE CENTRAL EFFECTS OF DFP

W. Clarke Wescoe 1, R. E. Green 1, B. P. McNamara 1, and Stephen Krop 1

1 Pharmacology Section, Medical Division, Army Chemical Center, Maryland

1. In cats and monkeys intravenous intocostrin (Squibb) in doses sufficient to produce complete skeletal and respiratory paralysis did not affect the EEG pattern.

2. Intravenous atropine and scopolamine produced a change in the control EEG characterized by a decrease in frequency and an increase in voltage.

3. Intravenous DFP produced a constant EEG effect characterized by an increase in frequency and a decrease in voltage.

4. The action of DFP could be prevented or abolished by the intravenous administration of atropine or scopolamine.

5. Atropine and scopolamine had no prophylactic or therapeutic effect on the convulsions caused by pentamethylenetetrazol (Metrazol), strychnine, or gammexane.

6. These data indicate that atropine prevents or annuls the central actions of ACh.

Submitted on September 11, 1947






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.