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Journal of Pharmacology And Experimental Therapeutics, Vol. 92, Issue 1, 43-48, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE ABSORPTION, DISTRIBUTION AND EXCRETION OF STREPTOMYCIN

E. K. Marshall JR. 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

Streptomycin has been determined by a chemical method in plasma and urine after intravenous and intramuscular injection in the dog and in man. It appears to be distributed in a percentage of the body weight which approximates extra-cellular water. Nearly all of the drug injected can be accounted for by excretion in the urine in the dog; this is not always true in the case of the human subject. The renal plasma clearance in both dog and man is lower than the glomerular clearance, where no allowance is made for a possible plasma binding of streptomycin.

We wish to thank Mildred Salchunis for technical assistance, and Dr. C. G. Zubrod for aid in the patient studies.

Submitted on September 11, 1947




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.