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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 4, 340-344, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF CHRONIC DDT INTOXICATION IN RATS ON LIPIDS AND OTHER CONSTITUENTS OF LIVER

HERBERT P. SARETT 1 and BERNARD J. JANDORF 1

1 From the Biochemistry Section, Medical Division, Army Chemical Center, Maryland

The chronic intoxication of rats with DDT administered either in oil or mixed in the diet leads to an increased per cent of total lipids in the liver.

With DDT in the diet there is an increase of 40 per cent in the size of the livers but no change in the percentage of water or of glycogen.

The increased total liver lipids are accompanied by a proportional increase in phospholipid content but a smaller increase in total cholesterol. The increase in cholesterol is proportional to the increase in weight of the livers.

The liver lipid changes after administration of DDT are not affected by the inclusion of an additional 0.2 per cent of choline chloride in the diet.

Submitted on August 6, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.