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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 4, 331-339, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THE LIVER IN THE DETOXICATION OF THIOPENTAL (PENTOTHAL) AND TWO OTHER THIOBARBITURATES

F. E. SHIDEMAN 1, A R. KELLY 1, and B. J. ADAMS 1

1 From the Dept. of Pharmacology, School of Medicine, University of Michigan, Ann Arbor, Michigan

1. Carbon tetrachloride liver damage in mice significantly prolonged the duration of effect of Pentothal Sodium and two other thiobarbiturates.

2. Subtotal hepatectomy in rats produced a significant prolongation of the duration of action of Pentothal.

3. Diminished blood flow through the liver, as produced by the Eck fistula technic in rats, increased the duration of action of Pentothal and the two other thiobarbiturates tested.

4. Pentothal was degraded in vitro by rat liver slices and mince.

Submitted on August 6, 1947




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.