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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 4, 317-323, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ASCORBIC ACID IN REDUCING THE INHIBITION OF BRAIN METABOLISM PRODUCED BY PENTOBARBITAL IN VITRO

MARGARET E. GREIG 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. Ascorbic acid can reduce the inhibition produced by pentobarbital in the oxidation of carbohydrate by rat brain in vitro.

2. It also reduces the aerobic glycolysis of brain produced by pentobarbital when glucose is substrate.

3. Cytochrome c increases the effect of ascorbic acid in some cases by further reducing the inhibition produced by pentobarbital.

Submitted on March 15, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.