FURTHER EXPERIMENTS IN AN ATTEMPT TO LOCATE THE SITE OF THE EMETIC ACTION OF THE DIGITALIS GLYCOSIDES

¹ From the Harrison Department of Surgical Research and the Department of Physiology, Schools of Medicine, University of Pennsylvania, Philadelphia

1. In chronic experiments on a large number of cats and dogs in good post-operative condition, glycosidic emetic responses were not prevented by deafferentation of the abdominal viscera, total hepatectomy, thorough cardiac denervation and extensive collective visceral deafferentation.

(2) In cats with complete visceral deafferentation strophanthidin emesis was blocked by the injection of nicotine.

(3) The experimental evidence favors the view that glycosidic nausea and vomiting is mainly of extravisceral origin, most probably central.