CERTAIN PHARMACOLOGIC PROPERTIES OF 4'-CARBOXYPHENYLMETHANESULFONANILIDE (CARONAMIDE), INCLUDING ITS EFFECT ON THE RENAL CLEARANCE OF COMPOUNDS OTHER THAN PENICILLIN

¹ Department of Pharmacology, The Medical Research Division, Sharp and Dohme, Inc., Glenolden, Pa.

The chemical properties of caronamide and methods for its determination in plasma and urine have been summarized.

Data have been presented from which the following four conclusions may be derived:

1. The renal clearances and over-all rate of elimination of caronamide appear tentatively to be equivalent to glomerular filtration rate in the dog.

2. The inhibitory effect of caronamide is on a renal tubular excretory transport mechanism; hence other compounds, i.e. p-aminohippurate and phenolsulfonephthalein, in addition to penicillin that are excreted by this system are affected similarly.

3. Caronamide did not influence other renal functions as indicated by the Tm of glucose or arginine, urea clearance, sulfonamide clearance, or creatinine clearance (glomerular filtration rate).

4. At concentrations of the drug that suppressed completely the tubular excretion of penicillin (2) it did not influence significantly heart or respiratory rate, systemic blood pressure, or kidney volume.