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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 3, 255-262, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics


EFFECT OF CARBON TETRACHLORIDE LIVER DAMAGE IN THE RABBIT AND RAT ON ACETYLCHOLINE ESTERASE ACTIVITY

SYDNEY ELLIS 1, SHIRLEY SANDERS 1, and OSCAR BODANSKY 1

1 Medical Division, Chemical Warfare Service, Edgewood Arsenal, Maryland

1. Liver damage resulting from the administration of carbon tetrachloride does not reduce the acetylcholine esterase activity of the plasma or liver of the rabbit. We have confirmed a previous report that in the rat plasma and liver activities are decreased in liver damage due to carbon tetrachloride.

2. This species difference is attributed to the differences in the choline ester hydrolyzing enzymes found to be present in the plasma and liver of the two animal species.

Submitted on July 31, 1947







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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.