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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 3, 246-249, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE ESTIMATION OF 4'-CARBOXYPHENYLMETHANE SULFONANILIDE (CARONAMIDE) IN BIOLOGICAL FLUIDS

BERNARD B. BRODIE 1, BETTY LEVY 1, and ELEANORE BERNSTEIN 1

1 Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital, New York, New York; Department of Medicine, New York University College of Medicine, New York, New York

Simple spectrophotometric methods are described for the estimation of caronamide (4'-carboxyphenylmethane sulfonanilide) in biological fluids. Caronamide is isolated from biological material by an extraction with chloroform at an acid pH. The compound is then returned to alkali and the concentration measured spectrophotometrically at 280 mµ. This method is specific in the case of the dog in that metabolic derivatives of caronamide do not interfere.

Another procedure measures the caronamide spectrophotometrically in protein fitrates of plasma. This method is simpler but less specific than the extraction procedure in that metabolic derivatives of caronamide interfere in the measurement.

Submitted on July 22, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.