JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 3, 210-217, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

ABSORPTION AND RENAL EXCRETION OF THE TETRAETHYLAMMONIUM ION

BARBARA R. RENNICK 1, GORDON K. MOE 1, RICHARD H. LYONS 1, SIBLEY W. HOOBLER 1, and ROSALIE NELIGH 1

1 Departments of Pharmacology and Internal Medicine, University of Michigan

1. TEA is quantitatively excreted by the kidneys in dogs and man after parenteral administration. In man 50% of an intravenous dose appears in the urine in 30 minutes, and 50% of an intramuscular dose in about 4 hours.

2. No delay in absorption from an intramuscular injection site was caused by incorporating the drug in a propylene glycol-beeswax mixture, but absorption was delayed after injection of the drug in Pitkin's menstruum.

3. The total excretion after oral administration in man is only 4 to 16% of the dose given. It is probable that poor absorption, rather than enteric or hepatic destruction, accounts for the low recovery.

4. The speed of excretion after intravenous injection in man, and the high extraction ratio obtained in the dog when the drug is infused into the renal artery, indicate that tubular excretion occurs in addition to glomerular filtration.

5. Since at high blood levels the extraction ratio falls below the glomerular filtration fraction, tubular reabsorption may also occur.

6. The drug should be used with caution in patients with severe renal damage.

Submitted on June 27, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.