JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ELLIOTT, H. W.
Right arrow Articles by JAMES, H. P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ELLIOTT, H. W.
Right arrow Articles by JAMES, H. P.
Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 2, 98-102, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

SOME EFFECTS OF 1-METHYL-4-PHENYL ETHYL ISONIPECOTATE (DEMEROL) AND 6-DIMETHYLAMINO-4,4,-DIPHENYL-3-HEPTANONE (AMIDONE) UPON THE METABOLISM OF RAT BRAIN TISSUE IN VITRO

HENRY W. ELLIOTT 1, ALBERT E. WARRENS 1, and HAL P. JAMES 1

1 From the Division of Pharmacology and Experimental Therapeutics and the Division of Obstetrics and Gynecology, University of California Medical School, San Francisco

The effects of demerol and amidone in vitro on the respiration and anaerobic glycolysis of brain tissue preparations have been studied by conventional manometric methods. Amidone is ten times as potent an inhibitor of glucose oxidation as demerol and stimulates oxygen uptake at low concentrations. The inhibitory action of these drugs is presumably due to an action on the dehydrogenases involved in glucose oxidation.

Submitted on May 27, 1947






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.