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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 2, 178-184, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

STUDIES IN VITRO AND IN VIVO ON THE INFLUENCE OF THE LIVER ON ISONIPECAINE (DEMEROL) ACTIVITY

E. LEONG WAY 1, ROLLAN SWANSON 1, and ABRAHAM I. GIMBLE 1

1 From the Department of Pharmacology, The George Washington University School of Medicine, Washington, D. C.

1. Evidence that the liver inactivates isonipecaine is indicated by the fact that effects and blood level of isonipecaine are increased in rats after partial hepatectomy.

2. In vitro findings on rat, dog and human liver support the in vivo results.

3. Under similar conditions in vitro, other tissues exhibited slight or no activity.

4. It is suggested that in patients with severe hepatic impairment, the desired therapeutic effect of isonipecaine can be obtained with smaller dosages.

Submitted on July 15, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.