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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 2, 157-160, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE TOXICITY AND GENERAL PHARMACOLOGY OF N1-p-CHLORO-PHENYL-N5-ISOPROPYL BIGUANIDE

K. K. CHEN 1 and ROBERT C. ANDERSON 1

1 From The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Indiana

1. The acute toxicity of N1-p-chlorophenyl-N5-isopropyl biguanide HCl has been compared with quinine 2HCl and quinacrine HCl in mice, rats, guinea pigs, and rabbits.

2. The biguanide has been repeatedly administered in various doses to rats. No pathologic lesions can be demonstrated, and death from large doses may be attributed to acute systemic effects.

3. The biguanide lowers blood pressure with an acceleration of respiratory rate in anesthetized cats.

4. With the exception of the isolated guinea pig's uterus, which responds by contraction, the biguanide has an inherently relaxing property on the isolated rabbit's uterus and intestine, and the isolated guinea pig's intestine.

5. The action of the biguanide on the blood sugar of rabbits is suggestive of a slight hypoglycemia.

Submitted on July 7, 1947




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.