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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 2, 133-139, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE ACUTE JOINT TOXICITY OF ATABRINE, QUININE, HYDROXYETHYLAPOCUPREINE, PAMAQUINE AND PENTAQUINE

GRAHAM CHEN 1 and E. M. K. GEILING 1

1 Department of Pharmacology, University of Chicago

The acute lethal toxicities of atabrine and quinine, quinine and hydroxyethylapocupreine, atabrine and pamaquine, quinine and pamaquine, quinine and pentaquine, were investigated by intraperitoneal injection in mice. It was found that the combinations of these antimalarials are different in their joint toxicity: (1) Atabrine and quinine, quinine and hydroxyethylapocupreine, act independently and similarly (2) Atabrine in sublethal doses and pamaquine act independently but diversely. (3) Quinine and pamaquine, quinine and pentaquine are synergistic in their joint action.

Submitted on June 23, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.