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Journal of Pharmacology And Experimental Therapeutics, Vol. 91, Issue 1, 77-83, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF DI-ISOPROPYL FLUOROPHOSPHATE ON NEUROMUSCULAR TRANSMISSION

CARLTON C. HUNT 1

1 Department of Pharmacology, Cornell University Medical College, New York, N. Y.

The effect of the intra-arterial injection of DFP and other cholinergic agents on the response of the cat gastrocnemius to maximal single nerve shocks is described.

1. DFP causes a potentiation like that seen following physostigmine.

2. DFP sensitizes the muscle to the close intra-arterial injection of acetylcholine.

3. DFP is less effective in antagonizing the depression of neuromuscular function caused by curare than is prostigmine.

4. Additional evidence is advanced for a direct action of prostigmine on skeletal muscle. ' A comparative study has been made of the actions of DFP, prostigmine, and physostigmine.

5. In relation to these data, the role of cholinesterase in neuromuscular transmission is discussed.

Submitted on June 4, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.