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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 4, 359-363, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF RUTIN ON PERMEABILITY OF CUTANEOUS CAPILLARIES

ANTHONY M. AMBROSE 1 and FLOYD DeEDS 1

1 Pharmacology Division, Bureau of Agricultural and Industrial Chemistry, Agricultural Research Administration, U.S. Department of Agriculture, Albany, California

Investigations have been made on the use of trypan blue for the testing of cutaneous capillary permeability in rabbits after applying chloroform to the skin; after intracutaneous injection of histamine, and after applying 30 mm. of mercury negative pressure to the skin.

The intravenous administration to rabbits of rutin in doses of 100 or 200 mgm. per kilo of body weight definitely decreased cutaneous capillary permeability as determined by the methods employed.

Submitted on May 21, 1947




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.