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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 4, 351-358, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF 2-AMINO-6-METHYLHEPTANE

EDWIN J. FELLOWS 1

1 Department of Pharmacology, Temple University, School of Medicine, Philadelphia, Pennsylvania

1. The threshold pain stimulus was elevated in cats after doses of 3.0-15.0 mgm. per kilogram of body weight of 2-amino-6-methylheptane hydrochloride intraperitoneally.

2. Local anesthesia was produced by tropical application of solutions of the hydrochloride or free base of 2-amino-6-methylheptane to rabbit's eyes.

3. Intravenously in dogs anesthetized with pentobarbital sodium, 2-amino-6-methylheptane hydrochloride exhibited 1/500-1/1000 the pressor activity of epinephrine.

4. As determined with a Cushny Myocardiograph, 2-amino-6-methylheptane hydrochloride was found to cause an increase in cardiac rate and amplitude of contraction.

5. Intravenously in dogs, anesthetized with pentobarbital sodium, doses of 0.5 to 1.0 mgm. per kilogram of body weight of 2-amino-6-methylheptane hydrochloride had no detectable effect on the small intestine, detrusor of the urinary bladder, urine secretion or respiration.

6. In general, concentrations of 1:10,000 to 1:200,000 of 2-amino-6-methylheptane hydrochloride caused relaxation of isolated segments of rabbit jejunum.

7. Intraperitoneally in rats, 2-amino-6-methylheptane hydrochloride was found to be almost entirely devoid of a central nervous system stimulating action in non-toxic doses.

8. Acute toxicity data were obtained on 2-amino-6-methylheptane hydrochloride in mice, rats, rabbits and guinea-pigs.

9. Large doses of 2-amino-6-methylheptane hydrochloride were administered daily for 30 days to rats, rabbits, and guinea-pigs. Examination of the tissues removed from these animals disclosed that this compound did not induce histropathologically demonstrable damage.

10. No histological evidence of irritation of the tracheo-bronchial tree mucosa was noted in rabbits or rats which inhaled 2-amino-6-methylheptane free base daily for 10 and 30 days respectively.

Submitted on May 12, 1947




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.