THE INTRAPERITONEAL TOXICITY OF SOME GLYCOLS, GLYCOL ETHERS, GLYCOL ESTERS, AND PHTHALATES IN MICE

¹ Toxicology and Pathology Sections, Medical Division, Edgewood Arsenal, Maryland

The acute, intraperitoneal median lethal doses for 16 solvents belonging to the glycol, glycol ether, glycol ester, and phthalate series were determined in Carworth Farms, female, albino mice, which were observed for 7 days following injection. The LD₅₀'s, in millimoles per kg., and the pathological changes Observed with some of the solvents up to 72 hours were as follows propylene glyco (127.87) diethylene glycol (91.69) ethylene glycol (90.55) triethylene glycol (54.27)-toxic reaction in spleen and thymus, renal glomerular and tubular damage, high white count, pulmonary congestion, and atelectasis dipropylene glycol (33.54)-renal tubular degeneration ethyl carbito (29.14)-toxic reaction in spleen, renal glomerular and tubular degeneration methyl cellosolve (28.25)-toxic reaction in spleen and lymph nodes, renal tubular degeneration ethyl ceflosolve (18.97) dimethyl phthaiate (18.75)-pulmonary congestion and atelectasis, toxic reaction in spleen and lymph nodes, renal tubular necrosis dibutyl phthalate (14.87)-pulmonary congestion, edema, and petechial hemorrhage, toxic reaction in spleen; renal tubular degeneration ethylene glycol monoacetate (13.93)-pulmonary congestion and atelectasis diethyl phthlate (12.37)- pulmonary congestion, edema, and petechial hemorrhage, toxic reaction in spleen, and renal tubular degeneration dioxane (8.97) glycol diacetate (8.14)- pulmonary congestion, renal tubular degeneration butyl carbitol (5.24)- pulmonary congestion and atelectasis, toxic reaction in spleen and lymphoid tissue, glomerular and tubular degeneration allyl diglycol carbonate (0.98)-pulmonary congestion, atelectasis, and edema, toxic reaction in spleen and lymphoid tissue, congestion of viscera, marked renal tubular damage. All fasting controls were negative.

Additional data include formulas, mOlecular weights, and specific gravities of the compounds; LD₅₀'s, with their respective standard errors, in ml./kg., gm./kg., and millimoles/kg.; regression line slopes with their standard errors; highest and lowest volumetric doses resulting in 0 and in 100 per cent mortality, respectively, during the first 24 hours following intraperitoneal injection and also for the 7 day observation period; and a tabulation, with pertinent pathological comments, of the relative severity of the major pathological changes observed.

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