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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 3, 271-275, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

DIGITALIS-LIKE ACTION OF SOME NEW GLYCOSIDES AND ESTERS OF STROPHANTHIDIN

K. K. CHEN 1 and ROBERT C. ANDERSON 1

1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6

1. The activity of 10 cardiac glycosides and 5 esters of strophanthidin has been determined in cats by intravenous injection: adonitoxin, cymarol, sarmentosides A and B, cheirotoxin, convalloside, desgluco-hellebrin, evonoside; methyl and potassium cymarylates; 3-dimethyl-, 3-diethyl-, 3-di-n-propyl-, and 3-di-n-butyl-, aminoacetyl strophanthidins; and 3-chioroacetyl anhydrostrophanthidin.

2. The significance of certain structural changes has been pointed out.

3. The potency of 6 glycosides (adonitoxin, cymarol, cheirotoxin, sarmentoside A, convalloside, and desgluco-hellebrin) has also been determined in frogs, and compared simultaneously with that of cymarin or ouabain. The order of activity of these substances is frequently reversed between cats and frogs.

Submitted on May 5, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.