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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 3, 254-259, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE BRONCHODILATOR ACTION OF COMPOUNDS STRUCTURALLY RELATED TO EPINEPHRINE

O. H. SIEGMUND 1, H. R. GRANGER 1, and A. M. LANDS 1

1 Pharmacological Research Laboratory, Frederick Stearns and Co., Division of Sterling Drug Inc., Detroit, Michigan

1. The bronchodilator effect of five homologues of epinephrine is described.

2. The N-isopropyl homologue, 1-(3', 4'-dihydroxyphenyl)-2-isopropylaminoethanol, was found to be the most effective bronchodilator. The removal of the alcoholic hydroxyl from the beta-carbon, to form 1-(3', 4'-dihydroxyphenyl)-2-aminoethane, resulted in a very great reduction in activity.

3. The branching of the N-alkyl group appears to markedly reduce toxicity.

4. The structural requirements important for effective bronchodilator activity are discussed.

Submitted on May 1, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.