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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 3, 224-232, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF COMPARATIVE ANTIHISTAMINIC ACTIVITY OF SIX COMPOUNDS

CHARLES A. WINTER 1

1 Merck Institute for Therapeutic Research, Rahway, N. J.

Six drugs have been tested in guinea pigs for antihistaminic potency against intravenous histamine, histamine aerosol, and on intestinal strips against histamine in vitro. The six compounds, in descending order of potency, are as follows: Neoantergan, Pyribenzamine, 3015 R.P., 3277 R.P., Benadryl, and Hetramine. Although three of the compounds had a lower acute toxicity than Neoantergan, the toxic/effective dose ratio was highest for that compound. Side reactions were least noticeable after Neoantergan, and most violent after 3277 R.P. Delayed deaths were observed after single injections of 3277 R.P. and Benadryl.

Submitted on April 21, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.