THE ACTION OF N,N-DIBENZYL-BETA-CHLOROETHYLAMINE (DIBENAMINE) IN HYPERTENSIVE DOGS

¹ Cardiovascular Department, Michael Reese Hospital, Chicago, Illinois Aided by the A. D. Nast Fund for Cardiovascular Research Supported in part by the Michael Reese Research Foundation

1. The intravenous administration of a single dose of the sympatholytic agent, N,N-dibenzyl-beta-chloroethylamine (Dibenamine), to both Goldblatt hypertensive and normotensive dogs induced in 5 of 7 animals a reduction in blood pressure of approximately one hour to 2 days duration sometimes with widely fluctuating pressure levels. Administration of the drug for a period of three weeks caused no maintained reduction in arterial pressure in hypertensive dogs.

2. The inhibition of the pressor phase of epinephrine action, with the appearance of its depressor action was demonstrated within two hours following the injection of dibenamine. This inhibitory action was mainly dissipated in 24 hours.

3. Dibenamine tended to inhibit the occurrence of epinephrine-induced ventricular tachycardia.