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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 2, 154-160, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

URINARY AND FECAL EXCRETION OF SULFANILAMIDE DERIVATIVES AFTER ORAL ADMINISTRATION TO RATS

ELIZABETH TAYLOR 1, FRED H. SNYDER 1, and FRED W. OBERST 1

1 Department of Biochemistry, Research Laboratories, The Wm. S. Merrell Co., Cincinnati

An investigation has been made of twenty previously unreported sulfanilamide derivatives.

Following oral administration to rats, ten of the compounds are excreted largely in the feces, one chiefly in the urine, and one is almost equally divided between the two materials.

Two 4-isothiocyanobenzenesulfonamides gave interesting and unexpected results. There appears to be a substance in normal rat feces, and in acetone extracts thereof, which in some way prevents full color development by these compounds after hydrolysis.

The remaining seven compounds are hydrolyzed with difficulty, and a satisfactory analytical method has not yet been worked out.

Submitted on March 31, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.