JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GREENBERG, L. A.
Right arrow Articles by LESTER, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GREENBERG, L. A.
Right arrow Articles by LESTER, D.
Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 2, 150-153, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLIC FATE OF ACETANILID AND OTHER ANILINE DERIVATIVES

III. The Role of p-Aminophenol in the Production of Methemoglobinemia After Acetanilid

LEON A. GREENBERG 1 and DAVID LESTER 1

1 Laboratory of Applied Physiolog, Yale University

(1) Contrary to the usually accepted theory, the occurrence of methemoglobin after administration of acetanilid is not due to p-aminophenol.

(2) Concentrations of p-aminophenol at or above 1 mg. per cent are required to produce methemoglobin in human blood in vitro.

(3) No free p-aminophenol was found in the blood after administration of acetanilid although methemoglobin was found.

(4) Free p-aminophenol was found in the blood after administration of the substance but no methemoglobin was found.

(5) Conjugated p-aminophenol does not in vivo or in vitro produce methemoglobin.

Submitted on March 25, 1947






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.