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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 2, 110-119, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF N-ALKYL HOMOLOGUES OF EPINEPHRINE

A. M. LANDS 1, V. L. NASH 1, H. M. McCARTHY 1, H. R. GRANGER 1, and B. L. DERTINGER 1

1 Pharmacological Research Laboratory, Frederick Stearns and Co., Division of Sterling Drug Inc., Detroit S1, Michigan

1. The replacement of the N-methyl group of epinephrine by -isopropyl or-sec. butyl groups results in compounds that are strongly depressor. Thisdepressor action is comparable to that sometimes elicitable with epinephrine.

2. The homologues of epinephrine have a direct stimulating effect on the heart.

3. The N-isopropyl and -sec. butyl homologues of epinephrine dilate thebronchioles, relax the small intestine, colon, and uterus, when present in highdilution.

4. The N-isopropyl homologue appears to be somewhat more effective thanthe N-sec. butyl homologue.

5. The possible role of these agents as sympathin I-mimetic agents is discussed.

Submitted on February 24, 1947




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E. Beccari, A. Beretta, and J. S. Lawendel
Resolution of Isopropyl Nor-Adrenaline into Optical Isomers and Their Pharmacological Potency Ratio
Science, August 28, 1953; 118(3061): 249 - 250.
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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.