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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 1, 83-87, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE ANTIHISTAMINE ACTION OF N-(2-PYRIDYL)-N-(2-THENYL)-N',N'-DIMETHYLETHYLENEDIAMINE HYDROCHLORIDE

HENRY M. LEE 1, WILLIAM G. DINWIDDIE 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Indiana

1. N-(2-Pyridyl)-N-(2-thenyl)-N',N'-dimethylethylenediamine HCl, designated as 01013, has a potent antihistamine action as proved by its inhibition of histamine effect on the isolated guinea pig's small intestines, the intact guinea pig placed in a histamine atmosphere, and the blood pressure of anesthetized cats.

2. The compound augments the pressor action of epinephrine.

3. Its toxicity in mice has been determined.

4. There is evidence that 01013 given by mouth may be efficacious in the treatment of hay fever.

Submitted on February 21, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.