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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 1, 42-45, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON STREPTOMYCIN

II. INACTIVATION OF STREPTOMYCIN UPON STANDING IN CERTAIN CULTURE MEDIA AND HUMAN SERUM

RICHARD J. HENRY 1, SAM BERKMAN 1, and RILEY D. HOUSEWRIGHT 1

1 From the Technical Laboratories of Camp Detrick, Frederick, Maryland

The activity of streptomycin was found to decrease while in solution in several bacteriological culture media, human serum, and human plasma. Maximum losses ranged up to 75%. Practically all the loss in activity occurred within the first twenty-four hours. The composition of the environment and the physical factors of time, temperature, and concentrations of streptomycin were found to be significant variables in this loss of potency. It is postulated that the observed loss in potency is the result of adsorption onto constituents of these environments.

Submitted on February 10, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.