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Journal of Pharmacology And Experimental Therapeutics, Vol. 90, Issue 1, 26-41, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF DRUGS ON THE CONTRACTILE FORCE OF A SECTION OF THE RIGHT VENTRICLE UNDER CONDITIONS OF AN INTACT CIRCULATION

MEASUREMENT OF ISOMETRIC SYSTOLIC TENSION BY MEANS OF CALIBRATED SPRINGS ATTACHED TO MYOCARDIOGRAPH LEVERS

ROBERT P. WALTON 1 and OLIVER J. BRODIE 1

1 From the Department of Pharmacology, Medical College of South Carolina, Charleston

A method is described by which figures can be obtained representing the isometric systolic tension of a section of myocardium under conditions of an intact circulation. The changes in such tension produced by a series of 10 drugs has been described with respect to dosage, time intervals and associated changes in blood pressure and stroke amplitude.

Submitted on February 4, 1947




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.